The scope of research and complexity of cases at the Peter Munk Cardiac Centre has made it a national and international source for discovery, education and patient care.
Research in the areas of structural and congenital heart disease intervention involves:
Minimally invasive (transcatheter, percutaneous) techniques for treating Congenital Heart Defects
Minimally invasive (transcatheter, percutaneous) techniques for treating Structural Heart Defects
Coronary Artery Disease
Heart Valvular Disease
Explore our research page to see how our researchers are shaping the future of cardiovascular care related to structural and congenital heart defects!
You may view a few of our current and recent research and clinical trials below.
A three-dimensional echocardiographic study on aortic-mitral coupling in transcatheter aortic valve replacement
Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure
Long-term outcomes after transcatheter aortic valve implantation: insights on prognostic factors and valve durability from the Canadian multicenter experience
Percutaneous Intervention to Treat Platypnea–Orthodeoxia Syndrome: The Toronto Experience
Transcatheter Pulmonary Valve Replacement With the Edwards Sapien System: The Toronto Experience
Incidence, predictors and clinical outcomes of residual stenosis after aortic valve-in-valve
Outcomes of Transcatheter Tricuspid Valve-in-Valve Implantation in Patients With Ebstein Anomaly
Early outcomes of percutaneous pulmonary valve implantation using the Edwards SAPIEN XT transcatheter heart valve system
Patient Selection Process for the Harmony Transcatheter Pulmonary Valve Early Feasibility Study. American Journal of Cardiology
Harmony Feasibility Trial: Acute and Short Term Outcomes with a Self-Expanding Transcatheter Pulmonary Valve. JACC Cardiovascular Interventions
Structural Heart Disease Intervention: The Canadian Landscape
Percutaneous left atrial decompression in adults with refractory cardiogenic shock supported with veno-arterial extracorporeal membrane oxygenation
Structural and congenital heart disease interventions: the role of three-dimensional printing
Management of post-myocardial infarction ventricular septal rupture
Transcatheter Tricuspid Valve-in-Valve Implantation for the Treatment of Dysfunctional Surgical Bioprosthetic Valves
Impact of Prosthesis-Patient Mismatch on Left Ventricular Myocardial Mechanics After Transcatheter Aortic Valve Replacement
Past and Current Clinical Trials
TAVI Protocol - Paravertebral Block Study (TAVI PVB)
The Multidisciplinary, Multimodality, But Minimalist Approach to Transfemoral Transcatheter Aortic Valve Replacement (3MTAVR)
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI)
5 Year Observation of Patients With PORTICO Valves (PORTICO-1)
RESPECT PFO - Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment - Clinical Trial
The SPACER Trial - Repair of Tricuspid Valve Regurgitation Using the Edwards TricuSPid TrAnsCatheter REpaiR System
Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects (CANOA) Trial
The RELIEF Trial: REduction or eLimination of mItral rEgurgitation in Degenerative or Functional Mitral Regurgitation With the CardiAQ-Edwards™ Transcatheter Mitral Valve
Use of Local Anesthetic (0.25% Bupivacaine) for Pain Control in Pediatric Cardiac Catheterization
Closure of Muscular Ventricular Septal Defects (VSDs) With the AMPLATZER Muscular VSD (MuVSD) Occluder
Melody TPV Post-Market Surveillance Study
Native Outflow Tract Transcatheter Pulmonary Valve Research Clinical Study
Toronto General Hospital
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Toronto, Ontario M5G 2C4
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Aortic Coarctation Following Aortic Valve Replacement: Problem Solving with Multimodality Cardiac Imaging
The Parable of the Errant Chest Drain in the Heart: Is There Only 1 Option?
Percutaneous Correction of Right Superior Vena Cava to Left Atrium
Spontaneous Thrombosis of a Left Circumflex Artery Fistula Draining Into the Coronary Sinus
3-Dimensional transesophageal echocardiography-guided closure of a Gerbode shunt due to CorMatrix patch dehiscence